Peptidomimetics Protocols
Wieslaw M. Kazmierski
A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.
Kategori:
Tahun:
1998
Edisi:
1
Penerbit:
Humana Press
Bahasa:
english
Halaman:
538
ISBN 10:
0896035174
ISBN 13:
9780896035171
Nama siri:
Methods in Molecular Medicine
Fail:
PDF, 27.95 MB
IPFS:
,
english, 1998
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